TABLE 1

The 50% inhibitory concentration values of T-2307 against respiratory chain complexes in Saccharomyces cerevisiae, Candida albicans, and bovine heart mitochondriaa

SourceIC50 (μM) ± SD
S. cerevisiaeC. albicansBovine heart
Complex INonexistence344 ± 32>3,000
Complex II755 ± 73>3,000Not determined
Complex II + III271 ± 37220 ± 55>3,000
Complex IV149 ± 23225 ± 23>3,000
  • a The values represent means and standard deviations of pooled data from two independent experiments, each performed in triplicate in S. cerevisiae and C. albicans mitochondria and 6 to 8 times in bovine heart mitochondria.