TABLE 1

Antimicrobial activity of APX001A against the main organisms and organism groups tested

Organism/organism groupNo. (cumulative %) of isolates with MIC/MEC of:a,bMIC50 (μg/ml)MIC90 (μg/ml)
≤0.002 μg/ml0.004 μg/ml0.008 μg/ml0.015 μg/ml0.03 μg/ml0.06 μg/ml0.12 μg/ml0.25 μg/ml0.5 μg/ml1 μg/ml2 μg/ml4 μg/ml8 μg/ml>c
Candida spp. (1,340 isolates)70 (5.2)213 (21.1)400 (51.0)215 (67.0)141 (77.5)190 (91.7)58 (96.0)7 (96.6)3 (96.8)0 (96.8)0 (96.8)43 (100.0)0.0080.06
Candida albicans (414 isolates)63 (15.2)141 (49.3)183 (93.5)26 (99.8)1 (100.0)0.0080.008
Candida glabrata (321 isolates)0 (0.0)2 (0.6)10 (3.7)11 (7.2)79 (31.8)167 (83.8)48 (98.8)4 (100.0)0.060.12
Candida parapsilosis (270 isolates)1 (0.4)30 (11.5)147 (65.9)70 (91.9)19 (98.9)3 (100.0)0.0080.015
Candida tropicalis (151 isolates)0 (0.0)3 (2.0)31 (22.5)85 (78.8)31 (99.3)1 (100.0)0.0150.03
Candida krusei (43 isolates)0 (0.0)43 (100.0)>2>2
Candida dubliniensis (49 isolates)3 (6.1)26 (59.2)19 (98.0)1 (100.0)0.0040.008
Candida lusitaniae (39 isolates)0 (0.0)11 (28.2)9 (51.3)11 (79.5)6 (94.9)1 (97.4)1 (100.0)0.030.12
Candida kefyr (13 isolates)0 (0.0)5 (38.5)4 (69.2)2 (84.6)2 (100.0)0.120.5
Other Candida spp. (40 isolates)3 (7.5)11 (35.0)10 (60.0)11 (87.5)2 (92.5)3 (100.0)0.0080.03
Cryptococcus neoformans var. grubii (30 isolates)0 (0.0)2 (6.7)3 (16.7)7 (40.0)7 (63.3)8 (90.0)1 (93.3)2 (100.0)0.250.5
Other yeasts (36 isolates)0 (0.0)1 (2.8)1 (5.6)4 (16.7)9 (41.7)2 (47.2)1 (50.0)2 (55.6)4 (66.7)3 (75.0)1 (77.8)8 (100.0)0.12>2
Aspergillus spp. (251 isolates)24 (9.6)170 (77.3)54 (98.8)2 (99.6)0 (99.6)1 (100.0)0.0150.03
Aspergillus fumigatus (182 isolates)2 (1.1)144 (80.2)35 (99.5)1 (100.0)0.0150.03
Aspergillus section Flavi (18 isolates)3 (16.7)6 (50.0)8 (94.4)1 (100.0)0.0150.03
Aspergillus section Nigri (23 isolates)17 (73.9)5 (95.7)1 (100.0)≤0.0080.015
Aspergillus section Terrei (10 isolates)0 (0.0)7 (70.0)3 (100.0)0.0150.03
Other Aspergillus spp. (18 isolates)2 (11.1)8 (55.6)7 (94.4)0 (94.4)0 (94.4)1 (100.0)0.0150.03
Other molds (49 isolates)7 (14.3)6 (26.5)8 (42.9)9 (61.2)1 (63.3)0 (63.3)0 (63.3)2 (67.3)3 (73.5)2 (77.6)6 (89.8)5 (100.0)0.06>8
  • a Twenty-four-hour MICs were recorded for Candida spp., 48-h MICs were recorded for other yeasts and C. neoformans var. grubii, 72-h MECs were recorded for Scedosporium spp., and 48-h MECs were recorded for Aspergillus spp. and other molds.

  • b Numbers in bold are modal MIC values.

  • c Greater than the highest dilution tested.