TABLE 2

Molecular correction with multiple algorithms from reanalysis of clinical trial data from Rwanda (a high-transmission study site) and Cambodia (a low-transmission site)a

CountryDrugs testedbClassification of recurrent infectionNo. of infections classified by algorithm
WHO/MMVNo glurp≥2/3 markersAllelic family switch
RwandaAR-LFRecrudescence17273659
Reinfections93837351
DHA-PPQRecrudescence36818
Reinfections40373525
CambodiaAS-AQRecrudescence5555
Reinfections0000
DHA-PPQRecrudescence45474747
Reinfections3111
AS-PYNRecrudescence12121212
Reinfections0000
  • a Full details of study sites and methodology are provided in Materials and Methods.

  • b AS-AQ, artesunate plus amodiaquine; DHA-PPQ, dihydroartemisinin plus piperaquine; AR-LF, artemether plus lumefantrine; AS-PYN, artesunate plus pyronaridine.