TABLE 1

The phenotypic/genotypic characteristics of M. tuberculosis isolates from the six patients who acquired cross-resistance to bedaquiline and clofazimine

Strain or patient IDaPrevious second-line treatment regimen/outcomebDST profile at start of BDQ-containing regimenBDQ exposure (mo)M. tuberculosis strain testing resultsTreatment outcome
pDST results for MIC (mg·liter−1) for:Genome coverage (×)WGSc
BDQ in 7H11BDQ in MGITCFZ in MGITRv0678pepQatpERv1979cNCBI accession no.Lineage
Strain
    H37Rv (NC_000962.3)0.030.250.2543.28WTWTWTWT
Patients
    1NOPre-XDR00.1250.50.571.67WTWTWTWTSRR9028486Delhi-CAS(3)Failure
40.5Not testedNot tested40.57779130_141-142_Ins-CWTWTWTSRR9028477
60.5Not testedNot tested58.11WTWTWTSRR9028476
9>0.54468.20WTWTWTSRR9028485
    2Am(8), Lfx, Cs, Eto, Z, E, B6/failureMDR00.030.50.580.97WTWTWT2221732_P478GSRR9028481Delhi-CAS(3)Cured
20.06Not testedNot tested127.50WTWTWTSRR9028488
50.54490.23779130_141-142_Ins-CWTWTSRR9028489
    3Am, Lfx, Eto, CS, Z, PAS, B6/failureMDR00.060.250.596.26WTWTWTWTSRR9028483Delhi-CAS(3.1.2)Failure
10.06Not testedNot tested86.92WTWTWTWTSRR9028490
60.2522100.78779048_V20GWTWTWTSRR9028494
    4Cm(12), Mfx, Cs, Eto, Cfz, Z, Amx-clv/failureXDR00.030.250.581.93WTWTWTWTSRR9028487Delhi-CAS(3)Still on treatment
20.03Not testedNot tested111WTWTWTWTSRR9028484
70.2524102.74779127_138-139_Ins-GWTWTWTSRR9028491
    5Cm(12), Mfx, Cs, Eto, Cfz, Z, PAS, Clr, Amx-clv, H, E, B6/failureXDR00.030.50.568.40WTWTWTWTSRR9028482Delhi-CAS(3)Failure
10.061Not tested125.22WTWTWTWTSRR9028493
30.1252Not tested116.61779127_138-139_Ins-GWTWTWTSRR9028480
60.12524109.03WTWTWTSRR9028478
    6Cm(12), Mfx, Cs, Eto, Cfz, LNZ, PAS, Z, Amx-clv, B6/failureXDR00.030.5199.35WTWTWTWTSRR9028479Euro-American -4.9Failure
10.54483.34779181_192-193_Ins-GWTWTWTSRR9028492
  • a ID, identifier.

  • b AM, amikacin; Amx-clv, amoxicillin-clavulanic acid; Cfz, clofazamine; Cm, capreomycin; Cs, cyclocerine; E, ethambutol; Eto, ethionamide; Lfx, levofloxacin; LNZ, linozolid; Mfx, moxifloxacin; PAS, para-aminosalicylic acid; B6, vitamin B6; Z, pyrazinamide. Numbers in parentheses indicate the duration of the administration of the antibiotic in months.

  • c WT, wild type.