TABLE 1

Posaconazole concentrations in central nervous system

Sample localizationTime between last posaconazole i.v. dose and samplingPosaconazole concentration (ng/g)Sample-to-plasma concentration ratio (%)
Plasma11 h 30 min2,500aNAb
Cerebrospinal fluid11 h 30 min200a8
Superficial brain parenchyma
    Sample 110 h 30 min2108
    Sample 210 h 30 min1205
Abscess pus
    Sample 111 h 10 min36515
    Sample 211 h 15 min1506
Surgical piece
    Sample 111 h 50 min35514
    Sample 211 h 50 min55022
Meninges12 h 30 min25010
  • a ng/ml.

  • b NA, not applicable.