TABLE 2

Changes in fungal CFU per gram of tissues for each treatment group compared with that prior to the start of therapy in both study arms

Treatment groupLog10 changea (95% CI) in fungal CFU/g by study arm and tissue type
Fungal burdenSurvival
KidneyBrainKidneyBrain
Vehicle control0.80 (−1.46 to 3.07)0.68 (−0.92 to 2.28)1.85 (−0.10 to 3.81)1.80 (−0.11 to 3.72)
Fosmanogepix, 104 mg/kg TID−0.50 (−2.76 to 1.76)0.13 (−1.47 to 1.73)−1.52 (−3.47 to 0.44)−1.46 (−3.37 to 0.46)
Fosmanogepix, 130 mg/kg TID0.69 (−2.95 to 1.57)0.06 (−1.54 to 1.66)−1.50 (−3.46 to 0.46)−1.29 (−3.20 to 0.63)
Fosmanogepix, 260 mg/kg BID−0.94 (−3.20 to −1.32)−0.73 (−2.33 to 0.87)−1.57 (−3.53 to 0.38)−1.44 (−2.29 to 0.51)
Fluconazole, 20 mg/kg QD1.08 (−1.18 to 3.34)1.19 (−0.42 to 2.78)2.11 (0.15 to 4.07)2.05 (0.13 to 3.96)
Caspofungin, 10 mg/kg QD−1.39 (−3.65 to 0.87)0.63 (−0.96 to 2.23)−2.78 (−4.74 to −0.82)−1.86 (−3.78 to 0.05)
  • a All values are compared with that of the 24-h control.