TABLE 5

Activity of GC-072 against drug-resistant strains of B. pseudomallei

TABLE 5
  • a A panel derived from the attenuated strain Bp82 (47) was used to assess single drug class resistance due to target mutations causing β-lactam resistance (e.g., ceftazidime resistance due to PenA β-lactamase point mutations or overexpression) or trimethoprim resistance (due to folA point mutations).

  • b The MIC against each strain was determined using broth microdilution assays. The data shown represent three biological replicates, each in duplicates, reporting modes from 6 data points.

  • c Values for ceftazidime and ciprofloxacin obtained with E. coli and P. aeruginosa type strains are within the expected CLSI range.