Disease severity endpoints (ITT-I analysis set)

  • a Wilcoxon rank-sum test.

  • b Satterthwaite t test.

  • c LS mean was calculated from a mixed model with repeated measures, adjusted for baseline mucus weight and treatment group as covariates and subject as a random effect. The P value represents the LS mean difference between treatment groups.

  • d AUC, area under the curve; CI, confidence interval; ITT-I, intent-to-treat infected (defined as all randomized subjects who received the challenge virus and at least one dose of study drug and met the criterion for laboratory-confirmed RSV infection [presence of viral shedding]); LS, least squares; RSV, respiratory syncytial virus; SE, standard error.