TABLE 1

Analysis of results of 3H-hypoxanthine incorporation assay to determine cross-resistance

TABLE 1
  • a In vitro IC50s of emetine dihydrochloride, (−)-R,S-dehydroemetine, and (−)-S,S-dehydroisoemetine in sensitive P. falciparum strain 3D7A and resistant P. falciparum strains Dd2 and W2, as well as ratios of in vitro cross-resistance of emetine dihydrochloride and (−)-R,S-dehydroemetine in both resistant strains (Dd2 and W2), using strain 3D7A as reference. ND, not determined.