TABLE 4.

Susceptibility of isolates in which patA or patB has been inactivated to ciprofloxacin and ethidium bromidea

IsolateGroupGene inactivatedMIC (μg/ml) of:
CipCip + resCip + NaOEtBrEtBr + resEtBr + NaO
R6Control0.50.50.2510.250.12
M42FQDR64321680.51
M298patA8880.50.50.5
M299patB8880.50.50.5
M45FQDR41140.51
M45ApatA1110.50.50.5
M45BpatB1110.50.50.5
M50FQDR64323240.51
M50ApatA4440.50.50.5
M50BpatB4440.50.50.5
M74FQDR64326440.51
M301patA8880.50.50.25
M305patB8880.50.50.25
M86FQDR20.50.540.50.5
M86ApatA10.50.50.50.50.5
M86BpatB10.50.50.50.50.5
M87FQDR3281640.51
M87ApatA8880.50.50.5
M87BpatB8880.50.50.5
M296FQDR20.5880.52
M304patA4120.50.50.25
M310patB412160.58
M297FQDR82880.51
M311patA8440.50.58
M311BpatB8440.50.58
M79FQ-R32321620.50.5
M316patA8880.250.50.5
M317patB8880.50.50.5
M83FQ-R64641844
M318patA1616160.50.50.5
M319patB1616160.50.50.5
M97FQ-R84840.51
M302patA4440.50.50.5
M306patB4440.250.50.5
M98FQ-R3223240.121
M314patA8880.50.50.5
M307patB88820.52
M100FQ-R82140.251
M315patA210.120.250.120.25
M308patB210.120.250.250.5
M55DR0.250.50.5160.51
M300patA2220.50.50.5
M55BpatB2220.50.50.5
M46DR0.250.50.5160.51
M46ApatA0.120.120.120.50.50.5
M46BpatB0.120.120.120.50.50.5
M295S10.50.2520.250.5
M303patA210.1210.51
M309patB412160.58
  • a Abbreviations are as defined for Table 3. MICs of each agent for the parent strains in which patA and patB are active are highlighted in boldface.