Table 1.

In vitro antifungal activities of E1210 against Candida spp. and Aspergillus fumigatus

Organism (no. of strains)CompoundMIC (μg/ml)
RangeMIC50MIC90
Candida albicans (52)E1210≤0.008–0.016≤0.008≤0.008
Fluconazole≤0.06–>640.130.25
Itraconazole0.008–>40.0160.016
Voriconazole≤0.004–>4≤0.004≤0.004
Amphotericin B0.25–0.50.250.5
Micafungin0.008–0.030.0160.016
Candida glabrata (44)E1210≤0.008–0.060.060.06
Fluconazole4–32416
Itraconazole0.25–20.51
Voriconazole0.06–10.130.25
Amphotericin B0.13–111
Micafungin0.008–0.030.030.03
Candida tropicalis (23)E1210≤0.008–0.030.0160.03
Fluconazole1–>64>64>64
Itraconazole0.03–>41>4
Voriconazole0.03–>4>4>4
Amphotericin B0.25–0.50.50.5
Micafungin0.0160.0160.016
Candida parapsilosis (26)E1210≤0.008–0.016≤0.0080.016
Fluconazole0.13–10.51
Itraconazole0.03–0.250.130.13
Voriconazole≤0.004–0.030.0160.016
Amphotericin B0.50.50.5
Micafungin0.13–111
Aspergillus fumigatus (20)E12100.03–0.130.060.13
Fluconazole>64>64>64
Itraconazole0.50.50.5
Voriconazole0.13–0.50.250.5
Amphotericin B0.25–10.50.5
Micafungin0.008–0.060.030.06