Table 2.

In vitro antifungal activities of E1210 against various clinical fungal isolates

Organism (no. of strains)MIC(s) (μg/ml) for individual isolate(s) (no. of isolates with MIC)
E1210FluconazoleItraconazoleVoriconazoleAmphotericin BMicafungin
Yeasts
    Candida krusei (4)2 (1), 4 (2), >32 (1)32 (3), 64 (1)0.13 (2), 0.25 (1), 1 (1)0.25 (3), 0.5 (1)0.5 (1), 1 (3)0.06 (2), 0.13 (2)
    Candida dubliniensis (7)≤0.008 (7)≤0.06 (1), 0.13 (2), 0.25 (4)0.016 (6), 0.03 (1)≤0.004 (1), 0.008 (3), 0.016 (2), 0.03 (1)0.13 (6), 0.25 (1)0.016 (6), 0.06 (1)
    Candida guilliermondii (1)≤0.00840.250.030.250.25
    Candida lusitaniae (1)0.060.50.0160.0080.250.06
    Cryptococcus neoformans (4)0.13 (1), 0.25 (2), 0.5 (1)2 (4)0.06 (3), 0.13 (1)0.03 (4)0.25 (4)>32 (4)
    Malassezia furfur (2)0.13 (1), 0.25 (1)2 (1), 8 (1)≤0.008 (2)0.03 (1), 0.25 (1)0.25 (1), 0.5 (1)16 (1), >32 (1)
    Trichosporon asahii (3)0.5 (1), 0.25 (1), 1 (1)1 (3)0.5 (3)0.06 (2), 0.13 (1)1 (1), 2 (2)>32 (3)
Filamentous fungi
    Aspergillus flavus (4)0.016 (2), 0.06 (1), 0.13 (1)>64 (4)0.25 (3), 0.5 (1)0.5 (3), 2 (1)1 (3), 2 (1)0.016 (1), 0.03 (3)
    Aspergillus niger (2)0.016 (1), 0.03 (1)>64 (2)2 (2)1 (1), 2 (1)0.13 (2)0.016 (1), 0.03 (1)
    Aspergillus terreus (1)0.13>640.130.510.016
    Fusarium solani (7)0.03 (4), 0.25 (1), 0.13 (1), >32 (1)>64 (7)>4 (7)4 (2), >4 (5)1 (3), 2 (4)>4 (7)
    Paecilomyces lilacinus (4)0.06 (4)32 (2), 64 (2)0.25 (1), 1 (3)0.13 (2), 0.25 (2)>16 (4)>32 (4)
    Rhizopus oryzae (5)1 (1), 4 (1), 8 (3)32 (1), >64 (4)0.016 (1), 0.13 (1), 2 (3)0.5 (1), 2 (1), >8 (3)0.13 (1), 0.25 (3), 1 (1)16 (1), >32 (4)
    Rhizopus microsporus var. rhizopodiformis (2)4 (1), 8 (1)>64 (2)1 (2)4 (1), 8 (1)1 (1), 0.5 (1)>32 (2)
    Mucor racemosus (1)8>641>80.06>32
    Scedosporium prolificans (1)0.03>64>4>4>16>4
    Pseudallescheria boydii (8)0.03 (2), 0.06 (5), 0.13 (1)16 (4), 32 (4)0.5 (6), 2 (2)0.13 (2), 0.25 (5), 0.5 (1)2 (1), 4 (1), 8 (1), 16 (1), >16 (4)0.25 (1), 0.5 (4), 1 (2), 2 (1)
    Cunninghamella bertholletiae (2)2 (1), 4 (1)>64 (2)1 (2)>8 (2)2 (2)>32 (2)
    Cladosporium carrionii (2)≤0.008 (1), 0.03 (1)8 (1), 16 (1)0.016 (1), 0.03 (1)0.06 (2)0.25 (1), 2 (1)0.5 (1), 4 (1)
    Cladosporium trichoides (2)0.016 (2)64 (2)0.03 (1), 0.13 (1)0.13 (1), 0.25 (1)0.25 (1), 1 (1)0.25 (1), 1 (1)
    Exophiala dermatitidis (3)≤0.008 (3)4 (1), 8 (1), 16 (1)0.06 (1), 0.13 (1), 0.5 (1)0.03 (2), 0.06 (1)0.25 (1), 0.5 (2)1 (1), >4 (2)
    Fonsecaea pedrosoi (3)≤0.008 (3)4 (1), 32 (2)0.06 (1), 0.13 (2)0.016 (1), 0.06 (1), 0.13 (1)0.13 (1), 0.5 (1), 1 (1)4 (2), >4 (1)
    Phialophora verrucosa (1)0.016640.060.251>4
    Phialophora repens (1)0.06320.50.130.25>4
    Phialophora parasitica (1)0.016>64>40.251>4
    Phialophora richardsiae (2)0.03 (1), 0.06 (1)64 (2)0.13 (1), 0.5 (1)0.25 (1), 0.5 (1)0.5 (1), 1 (1)1 (1), 2 (1)
    Rhinocladiella aquaspersa (1)0.066410.251>4
Dermatophytes
    Trichophyton rubrum (3)8 (3)1 (2), 2 (1)0.25 (3)0.06 (3)0.25 (3)≤0.03 (2), >32 (1)
    Trichophyton mentagrophytes (3)4 (2), 8 (1)0.5 (1), 4 (1), 8 (1)0.06 (1), 0.13 (1), 0.25 (1)0.016 (1), 0.13 (2)1 (3)≤0.03 (3)