Table 3.

In vitro antifungal activities of E1210 against fluconazole-sensitive and fluconazole-resistant Candida spp.

Fluconazole susceptibility of Candida spp. (no. of strains)CompoundMIC (μg/ml)
RangeMIC50MIC90
Susceptible (140)E1210≤0.008–4≤0.0080.06
Fluconazole≤0.06–320.58
Itraconazole0.008–40.130.5
Voriconazole≤0.004–>40.0160.13
Amphotericin B0.13–10.51
Micafungin0.008–10.0161
Resistant (18)E1210≤0.008–>320.0160.03
Fluconazole64–>64>64>64
Itraconazole0.06–>42>4
Voriconazole0.03–>4>4>4
Amphotericin B0.25–10.50.5
Micafungin0.008–0.130.0160.03