Table 2.

MIC values for ampicillin, P113, Phe-P-113, Nal-P-113, and Bip-P-113 in different pH conditions and concentrations of MgCl2

SpeciesMIC (μg/ml) in LYM brotha
ControlMgCl2 concn (mM)pH condition
0.51.52.56.55.54.5
APP-113PheNalBipP-113PheNalBipP-113PheNalBipP-113PheNalBipP-113PheNalBipP-113PheNalBipP-113PheNalBip
E. coli ATCC 259222512.512.53.16.2512.5253.16.2525506.256.2525>5012.56.2512.5506.253.112.5>5012.512.5>50>5012.512.5
S. aureus ATCC 2592312.512.56.251.563.1506.253.13.150>503.13.150>503.13.112.56.253.13.1505012.53.16.25506.253.1
S. aureus ATCC 2921312.512.56.251.563.112.56.251.563.12512.51.563.125>501.563.112.5>501.563.16.25>5012.56.253.150256.25
S. aureus ATCC 196366.2550256.256.25>502512.56.25>502512.56.25>50>50256.25>50253.16.25>50>506.256.25>50>506.253.1
P. aeruginosa ATCC 27853X25251.563.150503.13.150>503.16.2550>506.2512.512.5>501.566.2550>503.16.25>50>5012.56.25
P. aeruginosa ATCC 9027X12.5253.13.1>50506.253.1>50506.256.25>50>5012.56.25>50>506.2525>50>5012.525>50>50256.25
  • a X, ampicillin resistant; AP, ampicillin; Phe, Phe-P-113; Nal, Nal-P-113; Bip, Bip-P-113.