Table 1.

MICs and cyp51A point mutations of eight pan-azole-resistant isolates from a CPA patienta

IsolateDate of isolation (day/mo/yr)MIC (mg/liter)Amino acid substitutionb
AMBITRVORRAVPOS
F1162823/01/20040.06>8>884G138C
F1204107/05/20040.25>8>8>82–4G138C
F1276026/11/20040.125>8882G138C
F1277626/11/20040.125>82–42–41–2Y431C
F1286507/12/20040.125>8882G138C
F1353529/04/20050.125>8882G138C
F1374617/06/20050.06>8882G138C
F1374717/06/20050.06>8441G434C
  • a Data were determined from at least three separate experiments. AMB, amphotericin B; ITR, itraconazole; VOR, voriconazole; RAV, ravuconazole; POS, posaconazole.

  • b Sequence for all three codons of TGC.