Table 1.

MICs of amphotericin B for QC and reference strains as determined in eight laboratories at 48 h

QC or laboratory control isolateQC MIC range (mode),a μg/ml% CLSI MICs within rangeMIC range (mode),a μg/ml, determined by laboratory:
12345678
Paecilomyces variotii ATCC MYA-36301-4 (2)100ND1-2 (2)1-2 (2)ND1-4 (2)NDND1-2 (2)
Aspergillus flavus ATCC 2043040.5-4 (NA)1000.5-1 (0.5)NDND0.25-1 (1)bNDND0.5-2 (2)ND
Aspergillus fumigatus NCPF 7097NANANDNDNDNDND0.5-2 (1)NDND
Aspergillus fumigatus NCPF 7100NANANDNDNDNDND1-2 (1)NDND
Candida parapsilosis ATCC 220190.5-4 (2)91.70.5 (0.5)1-2 (2)0.5-4 (1)0.5-2 (1)ND0.5-4 (1)0.5-1 (1)ND
Candida krusei ATCC 62581-4 (2)1001 (1)1-4 (2)0.5-2 (1)1-2 (2)1-4 (2)1-2 (1)1-2 (2)1-2 (2)
  • a MICs were determined as recommended by the CLSI M38-A2 document (8). ND, Not determined. NA, QC MIC limits are not available, but the A. flavus strain is listed in the CLSI M38-A2 document as a reference isolate.

  • b MICs were outside the range for reference isolate A. flavus ATCC 204304 (2%).