Table 4.

Percentages of isolates of six Aspergillus spp. above the amphotericin B WT distribution from eight laboratories as determined by CLSI M38-A2 and EUCAST broth microdilution methods at 48 h

SpeciesECV, μg/ml (% of isolates above each WT distribution)a
≥95%≥97.5%>99%
A. fumigatus2 (0.3)/0.5 (7.6)/2 (0.3)2 (0.3)/1 (1.2)/2 (0.3)4 (0.1)/1 (1.2)/4 (0.1)
A. flavus2 (2.6)/2 (3.6)/2 (2.8)4 (0.3)/2 (3.6)/4 (0.3)4 (0.3)/2 (3.6)/4 (0.3)
A. nidulans4 (1.1)/2 (11.6)/4 (2.4)4 (1.1)/4 (5.8)/4 (2.4)4 (1.1)/4 (5.8)/8 (1.2)
A. niger2 (0)/0.5 (0)/2 (0)2 (0)/0.5 (0)/2 (0)4 (0)/0.5 (0)/4 (0)
A. terreus4 (3.9)/4 (5.3)/4 (4.3)4 (3.9)/4 (5.3)/4 (4.3)8 (0.2)/4 (5.3)/4 (0.7)
A. versicolor2 (8.1)/2 (4.5)/2 (4.5)2 (8.1)/4 (0)/2 (7.6)2 (8.1)/4 (0)/4 (0.6)
  • a Calculated ECVs comprising ≥95, ≥97.5, or ≥99% of the statistically modeled population, determined using CLSI/EUCAST/combined CLSI and EUCAST data.