Table 2.

In vitro activities of E1210 and comparators against amphotericin B-resistant A. terreus SC as determined by CLSI broth microdilution methodsa

Isolate no.MIC/MEC (μg/ml) forb,c:
AMBITRPSCVRCANFCSFE1210
44640.50.50.50.0080.120.015
61840.50.250.250.0080.120.03
8691210.510.0150.250.06
8693210.50.50.0150.250.06
869420.50.250.50.0080.120.03
8695210.510.0080.120.06
869620.250.250.250.0080.120.015
872220.50.510.0150.120.03
872320.50.250.50.0080.120.03
872720.50.510.0080.120.03
872820.50.50.50.0080.120.03
8729210.510.0080.120.03
873020.50.510.0080.120.03
8731242>80.0080.120.015
873320.50.510.0150.120.015
  • a The MICs and minimum effective concentrations (MECs) were determined after 48 h of incubation.

  • b The MICs for AMB (amphotericin B), ITR (itraconazole), PSC (posaconazole), and VRC (voriconazole) were read at complete (100%) inhibition.

  • c The MECs for ANF (anidulafungin), CSF (caspofungin), and E1210 were read as described in CLSI document M38-A2 (6).