Table 3.

In vitro activities of E1210 and comparators against itraconazole-resistant Aspergillus spp. as determined by CLSI broth microdilution methods

SpeciesIsolate no.MIC/MEC (μg/ml) fora:
ITRPSCVRCAMBANFCSFE1210
A. fumigatus SC8686>81210.0150.120.12
8687>81210.0150.120.06
8688>81110.0080.120.03
8689>81210.0150.120.06
8690>82810.0080.120.06
873741210.0150.120.03
8737>810.2510.0080.120.03
A. niger SC869841210.0080.120.008
3014120.50.0080.120.008
A. terreus SC873142>820.0080.120.015
  • a Definitions for MIC and MEC and all abbreviations are as described in Table 2. Resistance to itraconazole is defined as an MIC of ≥4 μg/ml (8, 29, 30).