Table 4.

Time-weighted change from baseline in virus titer for the intent-to-treat infected population

Population and time intervalValue for group receiving:
Peramivir (300 mg)Peramivir (600 mg)Oseltamivir
No. of patients testedChange in virus titeraPbNo. of patients testedChange in virus titeraPbNo. of patients testedChange in virus titera
Overall
    From day 1 to day 2201−1.10 ± 0.900.4278192−1.08 ± 0.820.2252195−1.04 ± 0.84
    From day 1 to day 3338−1.71 ± 1.210.1337349−1.71 ± 1.100.1778343−1.63 ± 1.11
    From day 1 to day 8323−2.97 ± 1.530.0674338−2.91 ± 1.440.2066331−2.82 ± 1.49
A/H1
    From day 1 to day 2115−1.18 ± 0.950.6244117−1.15 ± 0.900.4678111−1.06 ± 0.97
    From day 1 to day 3190−1.79 ± 1.260.5092198−1.81 ± 1.190.5204195−1.71 ± 1.22
    From day 1 to day 8182−3.20 ± 1.550.1735191−3.17 ± 1.420.4007187−3.04 ± 1.57
A/H3
    From day 1 to day 258−1.23 ± 0.680.038654−1.12 ± 0.520.312960−1.01 ± 0.60
    From day 1 to day 3106−1.87 ± 0.910.0218105−1.68 ± 0.710.2434107−1.58 ± 0.76
    From day 1 to day 8102−2.86 ± 1.280.0644103−2.57 ± 1.050.5459103−2.48 ± 1.01
B
    From day 1 to day 213−0.82 ± 1.020.161210−1.13 ± 0.930.834216−1.21 ± 0.73
    From day 1 to day 321−1.68 ± 1.260.189125−2.08 ± 1.130.679423−2.08 ± 1.00
    From day 1 to day 820−3.46 ± 1.310.112824−3.92 ± 1.610.877823−3.99 ± 1.24
  • a Expressed as log10 TCID50/ml. Values are means ± SD.

  • b Determined by the van Elteren test, which was stratified by current smoking behavior, composite symptom score at baseline, and country/region.