Table 6.

Summary of postbaseline minimum neutrophil count by grade (safety population)

Grade (no. of neutrophils/μl)No. (%) of patients
Phase II studyaPhase III studyb
Peramivir (n = 198)Placebo (n = 100)Peramivir (n = 723)Oseltamivir (n = 363)
Grade 0 (≥1,300/μl)151 (76.3)89 (89.0)557 (77.0)288 (79.3)
Grade 1 (≥1,000 and <1,300/μl)29 (14.6)7 (7.0)93 (12.9)41 (11.3)
Grade 2 (≥750 and <1,000/μl)14 (7.1)3 (3.0)60 (8.3)25 (6.9)
Grade 3 (≥500 and <750/μl)3 (1.5)1 (1.0)10 (1.4)7 (1.9)
Grade 4 (<500/μl)1 (0.5)0 (0.0)3 (0.4)2 (0.6)
  • a A placebo-controlled randomized study (12).

  • b An oseltamivir-controlled randomized study (our present study).