Table 4.

Influence of HIV, type of TB, RMP, gender, age and nutritional status (weight for age Z score) on pharmacokinetic parameters of PZA

ParameterNCmax(μg/ml)tmax (h)AUC0-5(μg·h/ml)
25 mg/kg35 mg/kg25 mg/kg35 mg/kg25 mg/kg35 mg/kg
Mean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valuea
HIV status
    Negative1530.91 (26.15-25.67)0.30449.20 (43.62-54.77)0.015b1.16 (0.91-1.42)0.6541.08 (0.79-1.37)0.009b122.9 (101.6-144.3)0.183180.1 (154.0-206.3)0.186
    Positive527.05 (19.34-34.76)40.84 (36.22-45.46)1.28 (0.69-1.86)1.50 (1.39-1.61)103.2 (75.80-130.6)160.5 (139.9-181.1)
Type of TB
    Extrapulmonary929.06 (22.29-35.830.67544.65 (35.77-53.53)0.3351.20 (0.84-1.57)0.9111.43 (0.75-1.53)0.737114.3 (84.97-143.6)0.686173.8 (140.6-207.00.895
    Pulmonary1130.67 (25.43-35.91)49.12 (44.06-54.19)1.18 (0.87-1.49)1.22 (0.89-1.55)121.1 (97.53-144.6)176.4 (147.2-205.6)
RMP
    No RMP934.07 (27.17-40.97)0.04950.70 (45.50-55.90)0.1171.12 (0.74-1.50)0.5411.25 (0.89-1.60)0.616138.2 (107.7-168.7)0.029b182.7 (146.2-219.3)0.498
    RMP included1126.58 (22.77-30.38)44.17 (36.94-51.40)1.25 (0.96-1.55)1.13 (0.78-1.49)101.5 (86.63-116.3)169.1 (143.3-194.9)
Gender
    Male1128.03 (24.31-31.75)0.28748.89 (42.84-54.95)0.3781.30 (1.03-1.57)0.2701.20 (0.87-1.52)0.895108.2 (92.19-124.1)0.212188.4 (164.8-212.1)0.138
    Female932.29 (24.38-40.19)44.93 (37.03-52.83)1.06 (0.67-1.46)1.17 (0.76-1.57)130.1 (95.55-164.6)159.1 (123.6-194.6)
Age200.9720.3730.9980.2580.5500.198
Nutritional status (Z score wt for age)200.5290.6760.7870.6930.6790.416
  • a P values are from independent t test(HIV, TB, RMP, gender) or linear regression analysis(age, nutrition).

  • b Significant at the 0.05 level.