Table 5.

Influence of HIV, type of TB, RMP, gender, age and nutritional status (weight for age Z score) on pharmacokinetic parameters of RMP

ParameterNCmax(μg/ml)tmax (h)AUC0-5(μg·h/ml)
10 mg/kg15 mg/kg10 mg/kg15 mg/kg10 mg/kg15 mg/kg
Mean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valuea
HIV status
    Negative76.85 (4.43-9.27)0.52012.52 (7.65-27.39)0.3501.612 (0.97-2.25)0.3901.56 (0.88-1.38)0.90118.41 (12.80-24.02)0.77436.12 (22.67-49.57)0.810
    Positive45.49 (0.06-10.92)10.24 (6.46-14.01)1.283 (0.48-2.08)1.52 (1.38-1.66)16.68 (0.24-33.12)38.40 (15.21-61.59)
Type of TB
    Extrapulmonary85.77 (3.23-8.31)0.18511.49 (7.19-15.80)0.7531.62 (1.09-2.15)0.2711.54 (0.97-2.11)0.99817.16 (10.10-24.230.57637.29 (23.97-50.620.870
    Pulmonary37.93 (3.66-12.20)12.21 (6.77-17.66)1.14 (0.17-2.46)1.54 (1.32-1.77)19.44 (8.70-30.19)36.03 (15.40-56.67)
Gender
    Male66.20 (3.81-8.60)0.86612.20 (9.09-15.31)0.7241.50 (1.43-1.57)0.9611.31 (0.87-1.75)0.17618.19 (11.28-25.09)0.86037.51 (28.27-46.75)0.901
    Female56.53 (1.96-11.12)11.09 (3.50-18.67)1.48 (0.26-2.70)1.82 (1.01-2.63)17.30 (6.03-28.57)36.28 (12.01-60.55)
Age110.2400.2320.3510.1530.4150.527
Nutritional status (Z score wt for age)110.3440.7740.4370.2170.8320.270
  • a P values are from independent t test (HIV, TB, RMP, gender) or linear regression analysis (age, nutrition).