Table 6.

Mean maximum serum INH concentrations and AUCs after administration of 5 and 10 mg/kg according to acetylator status

NAT2 statusNo.CmaxAUC0-5
5 mg/kg10 mg/kg5 mg/kg10 mg/kg
Mean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valuea
Fast82.16 (0.10-3.32)0.1396.69 (4.58-8.79)0.6504.28 (1.70-6.87)0.19612.89 (8.66-17.12)0.416
Intermediate43.64 (2.00-5.29)0.031b7.48 (4.51-10.53)0.039b7.14 (3.48-10.80)<0.001b15.79 (9.80-21.77)<0.001b
Slow84.00 (2.83-5.16)0.7149.84 (7.74-11.94)0.18912.38 (9.80-14.97)0.02430.12 (25.89-34.35)<0.001b
  • a From one-way ANOVA.

  • b Significant at the 0.05 level.