Table 2.

Mean maximum serum concentrations (Cmax), area under the curve (AUC), and mean time until maximum serum concentration is reached (tmax) with 95% confidence interval for INH, PZA, and RMP in children <2 years of age

ParameterINH (n = 20)PZA (n = 20)RMP (n = 11)
5 mg/kg10 mg/kgP valuea25 mg/kg35 mg/kgP valuea10 mg/kg15 mg/kgP valuea
Cmax(μg/ml)3.19 (2.39-3.99)8.11 (6.68-9.53)<0.001b29.95 (26.16-33.73)47.11 (42.64-51.58)<0.001b6.36 (4.45-8.27)11.69 (8.71-14.67)0.005b
tmax (h)0.70 (0.72-1.17)0.52(0.64-1.12)0.6401.44 (0.98-1.41)1.45 (0.96-1.41)0.9611.49 (1.07-1.91)1.54 (1.16-1.93)0.865
AUC (μg·h/ml)8.09 (5.76-10.42)20.36 (15.76-24.97)<0.001b118.01 (101.33-134.70)175.23 (155.50-194.96)<0.001b17.78 (12.81-22.76)36.95 (27.64-46.26)0.006b
  • a From paired t test comparing previous and revised doses.

  • b Significant on the 0.05 level.