Table 3.

Influence of HIV, type of TB, RMP, gender, age and nutritional status (weight for age Z score) on pharmacokinetic parameters of INH

ParameterNo.Cmax(μg/ml)tmax (h)AUC0-5(μg·h/ml)
5 mg/kg10 mg/kg5 mg/kg10 mg/kg5 mg/kg10 mg/kg
Mean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valueaMean (95% CI)P valuea
HIV status
    Negative153.19 (2.18-4.19)0.9908.50 (6.69-10.32)0.2290.98 (0.71-1.24)0.6880.76 (0.49-1.02)0.0787.39 (4.98-9.80)0.41319.54 (14.04-25.06)0.552
    Positive53.20 (1.25-5.15)6.91 (4.37-9.46)0.86 (0.21-1.52)1.26 (0.67-1.85)10.21 (1.98-18.44)22.81 (10.19-35.42)
Type of TB
    Extrapulmonary92.93 (1.89-3.97)0.5397.07 (5.17-8.98)0.1660.87 (0.50-1.23)0.5151.04 (0.64-1.44)0.2248.15 (3.86-12.44)0.96618.91 (11.10-26.73)0.567
    Pulmonary113.40 (2.06-4.75)8.95 (6.72-11.18)1.01 (0.68-1.34)0.75 (0.42-1.08)8.05 (4.88-11.22)21.55 (14.90-28-19)
RMP
    No RMP93.31 (1.43-4.07)0.7918.89 (6.03-11.75)0.3370.91 (0.52-1.30)0.7580.70 (0.36-1.05)0.1697.24 (3.97-10.51)0.49119.26 (11.05-27.47)0.667
    RMP included113.09 (0.98-2.45)7.46 (5.88-9.05)0.98 (0.66-1.30)1.02 (0.67-1.39)8.79 (5.03-12.56)21.26 (9.52-2.87)
Gender
    Male113.31 (2.05-4.56)0.7428.73 (6.87-10.60)0.3321.11 (0.79-1.44)0.0830.93 (0.57-1.28)0.6708.82 (5.13-12.51)0.47623.02 (16.58-29.46)0.19
    Female93.05 (1.82-4.28)7.34 (4.76-9.92)0.74 (0.42-1.07)0.83 (0.42-1.23)7.21 (3.81-10.60)17.11 (9.67-24)
Age200.044b0.0830.7640.787<0.001b0.007b
Nutritional status (Z score wt for age)200.2370.2280.9090.2070.7770.582
  • a P values are from independent t test (HIV, TB, RMP, gender) or linear regression analysis (age, nutrition).

  • b Significant at the 0.05 level.