Table 4.

Pm susceptibility and lipid A modifications of P. aeruginosa phoPQ mutants

Laboratory strain or clinical isolate(s)phoPQ allele (pmrAB allele, laboratory strain)Pm susceptibilityaLipid A modification
Addition of L-Ara4NAddition of C16:0Presence of 2OH-C12:0Removal of 3OH-C10:0
1026phoPQ+ (pmrAB+)S++
1812phoPQ+pmrAB)S+++
1995phoQ6pmrAB)R++++
2307ΔphoQpmrAB)R++++
2244ΔphoPQpmrAB)S++
2243ΔphoPQ (pmrAB+)S++
2326ΔphoQ (pmrAB+)R++++
1018phoQ21R++++
1597, 1021phoQ21R+++
1019, 1586, 1598phoQ21R++
1581, 1601phoQ21S++
1582phoQ22R+++
1565phoP23Q23R+++
1603phoP24Q24R+++
  • a Data represent the results of measurements by colistin agar dilution. S, susceptible (CST MIC ≤ 2 mg/liter); R, resistant (CST MIC ≥ 8 mg/liter).