TABLE 1.

Antifungal susceptibility of the five most frequent Candida species responsible for bloodstream infections according to recent exposure to fluconazole or caspofungin prior to diagnosis of fungemiaa

Exposure drug and antifungalNo preexposure recordedPreexposure recordedPb
No. of isolatesGMIC (mg/liter)No. of isolatesGMIC (mg/liter)
Fluconazole
    Total2,2890.77 (0.71-0.83)c1592.31 (1.65-3.23)<0.001
    C. albicans12910.24 (0.23-0.24)580.36 (0.25-0.51)0.053
    C. glabrata41313.97 (12.59-15.50)4618.05 (13.19-24.70)0.129
    C. parapsilosis2950.97 (0.86-1.08)231.62 (0.99-2.64)0.015
    C. tropicalis2260.84 (0.70-1.00)201.52 (0.76-3.01)0.040
    C. krusei6434.15 (29.88-39.02)1228.51 (10.78-75.41)0.402
Caspofungin
    Total19200.07 (0.07-0.08)610.16 (0.12-0.22)<0.001
    C. albicans9930.05 (0.05-0.05)130.09 (0.04-0.22)0.252
    C. glabrata3650.07 (0.07-0.08)210.12 (0.08-0.19)0.418
    C. parapsilosis2990.28 (0.26-0.31)190.32 (0.23-0.45)0.893
    C. tropicalis1990.06 (0.05-0.06)0
    C. krusei640.15 (0.13-0.17)80.19 (0.11-0.33)0.571
  • a Recent exposure was <30 days prior to diagnosis of fungemia, and data for incident episodes and first recurrences are included. GMIC, geometric mean MIC.

  • b Mann-Whitney test.

  • c Values in parentheses are 95% CIs.