TABLE 2.

Characteristics of patients and Candida sp. isolates responsible for incident fungemia according to recorded or not recorded recent exposured to fluconazole or caspofungin

Group and characteristicRecent exposure to fluconazoleRecent exposure to caspofungin
None recorded (n = 2,305)Recorded (n = 136)PNone recorded (n = 2,391)Recorded (n = 50)P
Patients
    Mean age (yr)56.9 (56.1-57.8)c50.7 (47.0-54.5)<0.00156.9 (56.0-57.7)42.7 (36.7-48.6)<0.001
    Male gendera1,392/2,305 (60.4)78/136 (57.4)0.5281,435/2,391 (60.0)35/50 (70.0)0.189
    Hematological malignancya411/2,305 (17.8)31/136 (22.8)0.168414/2,391 (17.3)28/50 (56.0)<0.001
    Intensive care unita1,073/2,305 (46.6)80/136 (58.8)0.0061,133/2,391 (47.4)20/50 (40.0)0.320
    Central venous cathetera1,723/2,305 (74.8)115/136 (84.6)0.0101,793/2,391 (75.0)45/50 (90.0)0.012
    After diagnosis of fungemia, prescription ofa:
        Fluconazole1,233/1,938 (63.6)43/129 (33.3)<0.0011,269/2,022 (62.8)7/45 (15.6)<0.001
        Caspofungin393/1,938 (20.3)52/129 (40.3)<0.001424/2,022 (21.0)21/45 (46.7)<0.001
    Death before day 30a859/2,185 (39.3)54/134 (40.3)0.856892/2,271 (39.3)21/48 (43.8)0.552
    Early death (<day 8)a481/846 (56.9)26/53 (49.1)0.318497/878 (56.6)10/21 (47.6)0.506
Isolatesb
    Mixed infectiona75/2,305 (3.3)3/136 (2.2)0.80077/2,391 (3.2)1/50 (2.0)1.000
    Non-C. albicans speciesa1,107/2,377 (46.6)89/139 (64.0)<0.0011,157/2,465 (46.9)39/51 (76.5)<0.001
    C. glabrata isolatesa393/2,377 (16.5)35/139 (25.2)0.011413/2,465 (16.8)15/51 (29.4)0.023
    Geometric mean MIC (mg/liter) for the isolate causing fungemia
        Fluconazole0.77 (0.71-0.83)c2.14 (1.51-3.04)<0.0010.80 (0.74-0.86)2.17 (1.23-3.82)<0.001
        Caspofungin0.07 (0.07-0.08)c0.08 (0.07-0.09)0.1990.07 (0.07-0.07)0.17 (0.13-0.23)<0.001
    Episodes due to at least one isolate with decreased susceptibility toa:
        Fluconazole452/2,305 (19.6)47/136 (34.6)<0.001480/2,391 (20.1)19/50 (38.0)0.004
        Caspofungin121/1,854 (6.5)10/106 (9.4)0.231119/1,910 (6.2)12/51 (24.0)<0.001
  • a The data indicate the number of individuals or isolates for whom the corresponding information was available/total number in the group (%).

  • b The total number of isolates studied during incident candidemia was 2,516.

  • c Values in parentheses in this row are 95% CIs.

  • d Recent exposure was <30 days prior to diagnosis of fungemia.