TABLE 1.

In vitro inhibitory effects of T-705 and ribavirin against VHF arenavirusesa

VirusVirus yield determination assayT-705Ribavirin
EC90 ± SDEC50 ± SDEC90 ± SDEC50 ± SD
GTOVPlaque43 ± 2015 ± 12303 ± 228239 ± 213
JUNV-RPlaque21 ± 1912 ± 1171 ± 8149 ± 71
MACVFocus-forming unit53 ± 1114 ± 5122 ± 1368 ± 21
  • a Data are the means and standard deviations (SD) from 3 or 4 separate experiments using Vero E6 cells. Values for 90 and 50 percent effective concentrations (EC90 and EC50, respectively) are expressed in μM.