TABLE 2.

Pharmacokinetic parameters for telavancin, vancomycin, and teicoplanin

ParameteraValue
TelavancinVancomycinTeicoplanin
Cmax (mg/liter)11.1 ± 2.513.9 ± 0.23.6 ± 0.9
AUC0-24 (mg/liter·h)95.7 ± 3.3193.4 ± 16.243.6 ± 11.2
t1/2 (h)7.4 ± 0.35.0 ± 0.414.0 ± 6.0
C at 12 h (mg/liter)2.1 ± 0.54.4 ± 1.01.6 ± 0.6
C at 24 h (mg/liter)<1<1
  • a C, concentration.