TABLE 1.

Combination indices for auranofin in combination with various potassium channel inhibitorsa

Channel inhibitorKv channel specificityCI (SEM)
Loratadine1.50.75 (0.02)
Flecainide1.31.4 (0.2)
Propafenone2.11.5 (0.1)
QuinidineBroad (1.5)0.78 (0.02)
  • a The CIs were calculated using the 50% effective concentrations whenever possible (or the maximum combination ratio).