Combination indices for auranofin in combination with various potassium channel inhibitorsa
Channel inhibitor | Kv channel specificity | CI (SEM) |
---|---|---|
Loratadine | 1.5 | 0.75 (0.02) |
Flecainide | 1.3 | 1.4 (0.2) |
Propafenone | 2.1 | 1.5 (0.1) |
Quinidine | Broad (1.5) | 0.78 (0.02) |
↵a The CIs were calculated using the 50% effective concentrations whenever possible (or the maximum combination ratio).