TABLE 1.

MICs and MBCs of NAI-107 and comparator agents against strains used in experimental infections

StrainPhenotypeCompoundMIC (μg/ml)MBC (μg/ml)
S. aureus
    4061aGISANAI-1070.51
Linezolid14
Vancomycin44
    1400bMRSANAI-1070.1250.125
Linezolid216
Vancomycin216
    1524aMRSANAI-1070.060.25
Vancomycin11
S. pneumoniae 2868aPenicillin intermediateNAI-1070.0150.015
Linezolid11
Penicillin G11
E. faecalis A533aVanANAI-1070.52
Linezolid264
E. faecium 569aVanANAI-10712
Linezolid432
  • a Clinical isolate.

  • b Laboratory isolate.