TABLE 2.

Efficacies of NAI-107 and comparator agents in murine lethal infection models induced by Gram-positive pathogens in immunocompetent or neutropenic animals

StrainCompoundRouteED50 (mg/kg) (95% confidence limits)
S. aureus GISA 4061bNAI-107i.v.14.2 (11.9-16.9)
s.c.25.1 (21.6-29.6)
Linezolidp.o.c17.8 (15.3-20.8)
Vancomycins.c.22.4 (18.0-27.9)
E. faecium VanA 569NAI-107i.v.2.3 (1.7-3.0)
s.c.4.5 (3.5-5.6)
Linezolidp.o.5.1a
E. faecalis VanA A533NAI-107i.v.2.8 (2.4-3.3)
s.c.8.0 (6.1-10.5)
Linezolidp.o.22.4 (18.6-27.0)
S. pneumoniae 2868NAI-107i.v.0.51 (0.42-0.62)
s.c.1.1 (1.0-1.4)
Linezolidp.o.15.9 (12.2-20.7)
Penicillin Gs.c.31.6 (27.2-36.7)
  • a The confidence limits could not be calculated because survival in all treated groups was either 0 or 100%.

  • b Infection was performed in neutropenic mice.

  • c p.o., per os.