TABLE 3.

Efficacies of NAI-107 and vancomycin following different treatment schedules in the model of rat endocarditis induced by S. aureus 1400

ExptGroupDose (mg/kg) and routeNo. of rats/groupNo. of survivors (%)No. of sterile heart vegetations (%)a
1Start of therapy100 (0)
End of therapy100 (0)0 (0)
NAI-1075 q12 i.v.115 (45.5)0 (0)
10 q12 i.v.1111 (100)3 (27.3)
20 q12 i.v.119 (82)5 (55.5)b
Vancomycin100 q12 i.m.108 (80)0 (0)
2Start of therapy80 (0)
End of therapy80 (0)0 (0)
NAI-10710 q12 i.v.119 (82)4 (44.4)c
20 q24 i.v.1010 (100)7 (70)d
Vancomycin100 q12 i.m.109 (90)0 (0)
  • a Determined in survivors.

  • b P < 0.05 compared to control groups, NAI-107 at 5 mg/kg, and vancomycin (Fisher's exact test).

  • c P < 0.05 compared to control groups and vancomycin (Fisher's exact test).

  • d P < 0.001 compared to control groups and vancomycin (Fisher's exact test).