TABLE 4.

Trough plasma levels of NAI-107 and vancomycin after the last treatment on days 2 and 5 in the rat endocarditis model

ExptGroupDose (mg/kg) and routeTrough plasma level (μg/ml) on day:
+2+5
1NAI-1075 q12 i.v.4.7 ± 1.36.8 ± 2.2
10 q12 i.v.13.5 ± 2.316.6 ± 2.7
20 q12 i.v.23.7 ± 4.330.4 ± 3.6
Vancomycin100 q12 i.m.2.4 ± 1.42.3 ± 1.4
2NAI-10710 q12 i.v.10.4 ± 2.213.4 ± 4.4
20 q24 i.v.9.4 ± 1.813.0 ± 3.6
Vancomycin100 q12 i.m.2.1 ± 1.62.5 ± 1.1