TABLE 2.

Characteristics of CF patients with S. aureus respiratory infection who were treated with LZD from 2000 to 2006

CharacteristicAll patients (n = 77)Patients with LRSA infection (n = 8)Patients with LSSA infection (n = 69)P valuea
No. (%) patients of female gender41 (53.3)4 (50.0)37 (53.6)1.0
Mean ± SD age (yr)b14.6 ± 9.613.6 ± 9.014.8 ± 9.80.62
No. (%) of patients with delta F508c45 (58.4)4 (50.0)41 (59.4)0.71
No. (%) of Caucasian patients74 (96.0)8 (100)66 (95.7)1.0
LZD courses in 7 yr
    Mean ± SD7.2 ± 8.218.8 ± 14.15.9 ± 6.10.001
    Median (interquartile range)4 (1-11)15.5 (8-27)4 (1-8)
LZD exposure over 7 yr (days)d
    Mean ± SD245.9 ± 331.3546.5 ± 240.2211.0 ± 323.8<0.001
    Median (interquartile range)98 (35-336)467 (371-691)74 (28-205)
LZD exposure/yr in pre-LRSA period (days)d
    Mean ± SD35.6 ± 49.183.1 ± 50.030.1 ± 46.3<0.001
    Median (interquartile range)14 (5-45)75 (44-116)11 (4-29)
Additional no. of antibiotics over 7 yr
    Mean ± SD6.0 ± 9.613 ± 20.05.2 ± 7.40.07
    Median (interquartile range)3 (1-8)8 (4-9)2 (1-7)
Additional no. of antibiotics/yr in pre-LRSA period
    Mean ± SD0.9 ± 1.72.3 ± 4.30.7 ± 1.00.11
    Median (interquartile range)0.4 (0.1-1.0)0.8 (0.5-1.7)0.3 (0.1 ± 1.0)
No. of hospitalizations in 7 yr
    Mean ± SD6.4 ± 9.112.8 ± 19.65.7 ± 6.90.18
    Median (interquartile range)3 (1-10)6 (2.5-12)3 (1-10)
No. of hospitalizations/yr in pre-LRSA period
    Mean ± SD0.9 ± 1.52.0 ± 3.70.8 ± 1.00.38
    Median (interquartile range)0.4 (0.1 ± 1.4)0.7 (0.2 ± 1.8)0.4 (0.1 ± 1.4)
No. (%) of patient deaths5 (6.5)1 (12.5)4 (5.8)
No. (%) of patient lung transplants8 (10.4)2 (25.0)6 (8.7)
  • a Comparison of LRSA and LSSA groups using Wilcoxon rank-sum or Fisher's exact test.

  • b Age at the midpoint of the year 2000.

  • c Homozygous.

  • d Cumulative.