TABLE 2.

Characteristics of patients in the MRSA and MSSA cohort. P values correspond to Cochran's Q statistic or Friedman ranks sum test, whenever appropriate

CharacteristicValuea
MRSA cohortMSSA cohort
BSINControlsNP valueBSINControlsNP value
Female96 (39)248230 (51)453<0.05231 (37)618543 (46)1,170<0.01
Age (yr)b69 (58-77)24867 (54-79)4530.4266 (53-76)61867 (54-77)1,1700.36
Transfer from another institution38 (18)21144 (11)391<0.0587 (16)539114 (11)1,021<0.05
>2 hospital stays in previous yr80 (38)21190 (23)391<0.01131 (24)539177 (17)1,021<0.01
Emergency admission181 (73)248283 (62)453<0.01496 (80)618784 (67)1,168<0.01
Antibiotic therapy before enrollment148 (60)248239 (53)4530.27195 (32)618467 (40)1,170<0.01
Surgery before enrollment60 (24)248110 (24)4530.10106 (17)618210 (18)1,1700.65
Length of stay before enrollmentb (days)4 (0-12)2483 (1-11)4530.061 (0-6)6182 (0-6)1,1700.07
Admission diagnosis
    Cardiovascular disease38 (15)24881 (18)4530.54111 (18)618266 (23)1,170<0.01
    Connective tissue disease4 (2)2481 (0)45312 (2)61814 (1)1,1700.50
    Dermatological causes3 (1)2486 (1)4531.0011 (2)61816 (1)1,1700.21
    Endocrine/metabolic causes8 (3)24812 (3)4530.7513 (2)61841 (4)1,1700.16
    Gastrointestinal causes36 (15)24879 (17)453<0.0550 (8)618155 (13)1,170<0.01
    Genitourinary causes28 (11)24853 (12)4530.9642 (7)61885 (7)1,1700.25
    Gynecologic causes02483 (1)4532 (0)61810 (1)1,1700.26
    Hematologic causes3 (1)24819 (4)453<0.0521 (3)61824 (2)1,1700.08
    Infectious disease55 (22)24823 (5)453<0.01149 (24)61887 (7)1,170<0.01
    Neurological causes9 (4)24839 (9)453<0.0548 (8)618103 (9)1,1700.23
    Oncologic causes22 (9)24843 (9)4530.6147 (8)61891 (8)1,1700.98
    Orthopedic causes8 (3)24818 (4)4530.1026 (4)61861 (5)1,1700.38
    Pulmonary causes21 (8)24832 (7)4530.8934 (6)618108 (9)1,1700.05
    Trauma5 (2)24816 (4)4530.0729 (5)61839 (3)1,1700.28
    Undetermined8 (3)24828 (6)4530.1923 (4)61870 (6)1,170<0.05
Charlson Comorbidity Index
    Charlson scoreb3 (2-5)2482 (1-3)453<0.012 (1-4)6182 (0-3)1,170<0.01
    Myocardial infarct37 (15)24840 (9)453<0.0571 (11)618125 (11)1,1700.93
    Congestive heart failure57 (23)24890 (20)4530.54103 (17)618167 (14)1,1700.14
    Cerebrovascular disease41 (17)24848 (11)453<0.0563 (10)618139 (12)1,1700.48
    Chronic pulmonary disease43 (17)24859 (13)4530.2667 (11)618155 (13)1,1700.10
    Mild liver disease10 (4)24822 (5)4530.9626 (4)61830 (3)1,1700.11
    Severe liver disease22 (9)24820 (4)4530.0628 (5)61834 (3)1,170<0.05
    Severe renal disease68 (27)24876 (17)453<0.01133 (22)618157 (13)1,170<0.01
    Peripheral vascular disease35 (14)24847 (10)4530.4567 (11)618128 (11)1,1700.30
    Connective tissue disease37 (15)24840 (9)4530.0671 (11)618125 (11)1,1700.28
    Peptic ulcer12 (5)24824 (5)4530.9031 (5)61861 (5)1,1700.26
    Diabetes82 (33)24878 (17)453<0.01125 (20)618214 (18)1,1700.84
    Diabetes with end organ damage33 (13)24819 (4)453<0.0144 (7)61845 (4)1,170<0.01
    Hemiplegia/paraplegia20 (8)24815 (3)4530.0621 (3)61848 (4)1,1700.25
    Cancer/leukemia47 (19)24898 (22)4530.47113 (18)618195 (17)1,1700.76
    Metastatic solid tumor17 (7)24836 (8)4530.9742 (7)61861 (5)1,1700.64
    AIDS0 (0)2482 (0)4534 (1)6185 (0)1,1700.72
    Dementia12 (5)24816 (4)4530.8819 (3)61846 (4)1,1700.72
Indwelling device at enrollment
    Intubation33 (13)24841 (9)4530.1355 (9)61853 (5)1,170<0.01
    Central venous catheter112 (46)246108 (24)451<0.01209 (34)617146 (12)1,169<0.01
    Arterial vascular access40 (16)24845 (10)453<0.0571 (11)61878 (7)1,170<0.01
    Peripheral vascular access181 (73)247296 (67)444<0.05448 (73)616759 (65)1,162<0.01
    Urinary catheter126 (51)245161 (36)451<0.01215 (35)618263 (23)1,165<0.01
    Tracheostomy9 (4)24811 (2)4530.4819 (3)61811 (1)1,170<0.01
    Nasogastric tube54 (22)24760 (13)453<0.0174 (12)61871 (6)1,168<0.01
    Wound drainage tube41 (17)24853 (12)4500.0843 (7)61872 (6)1,1690.90
Characteristics of the BSI
    Polymicrobial BSI22 (9)24554 (9)607
    Hospital onset of BSI (>48 h)139 (56)248275 (44)618
Source
    Bone/joint5 (2)24822 (4)618
    CNSc foci024812 (2)618
    Intervention2 (1)2487 (1)618
    Ear-nose-throat6 (2)2487 (1)618
    Intra-abdominal10 (4)24811 (2)618
    Intravascular59 (24)248156 (25)618
    Lower respiratory tract28 (11)24863 (10)618
    Skin/soft tissue53 (21)248126 (20)618
    Urinary-genital12 (5)24822 (4)618
    Unknown73 (29)248192 (31)618
Outcome
    Died in hospital85 (36)23941 (9)446<0.01138 (23)60476 (7)1,166<0.01
    Died within 30 days after enrollment74 (31)24236 (8)429<0.01126 (22)58583 (8)1,082<0.01
    Length of stay after enrollmentb (days)16 (6-32)2407 (3-18)447<0.0115 (7-26)6048 (4-14)1,166<0.01
  • a Percentages are in parentheses.

  • b Median and interquartile range are shown.

  • c CNS, central nervous system.