Structure of PFA and its in vitro antifungal activity compared to that of AMB

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  • a Broth microdilution assays were performed according to CLSI guidelines. RPMI, RPMI 1640 medium; SBD, Sabourand dextrose broth.

  • b IC50, concentration that results in 50% growth inhibition relative to that of the controls. MIC, the lowest concentration that allows no detectable growth. MFC, minimum fungicidal concentration, i.e., the lowest concentration that kills 100% of the cells. The data are in μg/ml and are average values from duplicate experiments.