Table 2.

Summary of azole resistance caused by mutations in the A. fumigatus CYP51A genea

AzoleResistance of strain with mutation:
M220G54G448L98-TR*
ItraconazoleRRRR
PosaconazoleRRSR
VoriconazoleISRR
  • a Data are a simplified version of Table 3 in the work of Howard et al. (8). R, resistance; S, susceptibility; I, intermediate or variable resistance or sensitivity; L98-TR*, L98 mutation associated with a tandem repeat in the gene promoter (it is unclear whether either mutation has an effect in isolation [11, 14]). The wild type was susceptible to all azoles.