Table 1.

Percent decrease in the number of CFU per biofilm when 24-h-old P. aeruginosa biofilms grown in different model systems were treated with TOB or a combination of TOB and a QSI (BH or CA)

P. aeruginosa strainTreatmentAvg % decrease ± SD in CFU obtained in different model systemsa
MHSCFMMLCWPBCWB
PAO1TOB45.5 ± 14.239.9 ± 18.983.3 ± 7.835.2 ± 21.7
TOB-BH88.6 ± 7.280.9 ± 4.997.0 ± 2.480.6 ± 11.4
TOB-CA89.4 ± 1.986.9 ± 11.293.3 ± 3.777.0 ± 5.0
ATCC 9027TOB6.3 ± 10.35.8 ± 7.62.1 ± 17.834.6 ± 18.9
TOB-BH82.3 ± 10.372.9 ± 4.544.9 ± 7.689.5 ± 3.2
TOB-CA90.2 ± 1.576.3 ± 9.542.9 ± 13.780.2 ± 2.2
  • a All combined treatments were significantly more effective than treatment with TOB alone (P < 0.05). MH, Mueller-Hinton; SCFMM, synthetic cystic fibrosis medium with mucin; LCWPB, Lubbock chronic wound pathogenic biofilm; CWB, collagen wound biofilm.