Table 1.

Top 20 LasB inhibitors ranked by Ki value

RankStructureKi (μM)
1HS-CH2-CO-Trp-Tyr-NH20.0405
2HS-CH2-CO-Phe-Tyr-NH20.041
3HS-CH2-CO-Phe-Gln-NH20.754
4HS-CH2-CO-Tyr-Val-NH20.768
5HS-CH2-CO-Trp-Ile-NH21.03
6HS-CH2-CO-Trp-Phe-NH21.10
7HS-CH2-CO-Ile-Leu-NH21.26
8HS-CH2-CO-Ile-Val-NH21.83
9HS-CH2-CO-Ile-Tyr-NH22.06
10HS-CH2-CO-Tyr-Tyr-NH22.08
11HS-CH2-CO-Phe-Met-NH22.82
12HS-CH2-CO-Tyr-Arg-NH22.95
13HS-CH2-CO-Ile-Thr-NH23.41
14HS-CH2-CO-His-Ala-NH23.62
15HS-CH2-CO-Met-Tyr-NH23.65
16HS-CH2-CO-Trp-Leu-NH23.66
17HS-CH2-CO-Ile-Gln-NH23.73
18HS-CH2-CO-Met-Lys-NH23.86
19HS-CH2-CO-Trp-Val-NH24.07
20HS-CH2-CO-Phe-Ile-NH24.47