Table 4.

Distribution by influenza virus subtype and IC50 of neuraminidase inhibitors at baseline

Virus subtype and parameteraValue for group
Overall300 mg600 mg
nPeramivirOseltamivirZanamivirnPeramivirOseltamivirZanamivirnPeramivirOseltamivirZanamivir
A/H116b7b9b
    Mean21.7987.111.4222.0283.521.4421.6289.911.41
    SD2.1216.070.101.5316.730.112.5715.940.09
    Min16.1957.421.2619.2057.421.2616.1958.281.27
    Median21.97100.01.4221.9476.391.4221.99100.01.41
    Max25.02100.01.6224.13100.01.6225.02100.01.56
A/H31349
    Mean0.850.712.110.830.662.120.860.732.11
    SD0.100.110.160.100.110.080.100.110.19
    Min0.720.541.900.720.542.030.740.541.90
    Median0.830.702.070.820.642.130.830.732.07
    Max1.020.882.430.950.812.191.020.882.43
A/-110
    Mean23.2168.411.4623.2168.411.46
    SD
    Min23.2168.411.4623.2168.411.46
    Median23.2168.411.4623.2168.411.46
    Max23.2168.411.4623.2168.411.46
B330
    Mean3.4818.069.433.4818.069.43
    SD0.062.530.300.062.530.30
    Min3.4115.149.123.4115.149.12
    Median3.4919.339.463.4919.339.46
    Max3.5319.709.723.5319.709.72
Unknown101
    Mean3.7514.769.483.7514.769.48
    SD
    Min3.7514.769.483.7514.769.48
    Median3.7514.769.483.7514.769.48
    Max3.7514.769.483.7514.769.48
  • a Min, minimum; Max, maximum.

  • b Except for 4 failures in identification due to small sample volume, the H274Y mutation was identified in 12 patients (300-mg group, 5 patients; 600-mg group, 7 patients).