Table 1.

Eradication failures and resistance rates

AgentPrior treatment% resistance (no. of resistant strains/no. tested)aMIC of agent
With AMX MIC (μg/ml) of:Other resistance
≥0.06≥0.550%90%Range
AMXNone13.6 (3/22)0 (0/22)<0.0150.06<0.015–0.12
One failure26.5 (56/211)0.9 (2/211)<0.0150.12<0.015–0.5
Two failures49.5 (49/99) ++ ###6.1 (6/99) #0.030.25<0.015–4
Three failures72.7 (8/11) +++ ##18.2 (2/11) ##0.120.5<0.015–4
CLRNo treatment9.1 (2/22)0.030.25<0.015–8
One failure89.6 (189/211) +++1632<0.015–64
Two failures88.8 (88/99) +++1632<0.015–64
Three failures72.7 (8/11) +++1664<0.015–64
MNZNone13.6 (3/22)280.25–32
One failure4.7 (10/211)120.5–32
Two failures72.7 (72/99) +++ ###16641–64
Three failures72.7 (8/11) ++ ###16324–32
  • a AMX resistance, MIC ≥ 0.06 μg/ml; AMX high-level resistance, MIC ≥ 0.5 μg/ml; CLR resistance, MIC ≥ 1μg/ml; MNZ resistance, MIC ≥ 8 μg/ml. ++, P < 0.01 versus results for nontreatment group; +++, P < 0.001 versus results for nontreatment group; #, P < 0.05 versus results for one-failure group; ##, P < 0.01 versus results for one-failure group; ###, P < 0.001 versus results for one-failure group.