Table 1.

Sequences and activities of six different peptoids and gentamicin against BCG and M. tuberculosis bacteriaa

NameSequence (amino to carboxyamide)MIC (μM)
BCGbM. tuberculosis H37Rvc
Peptoid 1H-(NLys-Nspe-Nspe)4-NH212.5–2514.1
1-C134merH-Ntridec-NLys-Nspe-Nspe-NLys-NH26.36.6
14merH-NLys-Nspe-Nspe-NLys-NH2>100NDd
1-Pro9H-(NLys-Nspe-Nspe)2-NLys-Nspe-L-Pro-NLys-Nspe-Nspe-NH212.5–2514.5
1-11merH-(NLys-Nspe-Nspe)3-NLys-Nspe-NH212.5–2514.46
1-NssbH-(NLys-Nssb-Nssb)4-NH2>100>100
Gentamicin25ND
  • a The MIC is the concentration at which no bioluminescence or lack of color change was observed in the two different assays used. MICs are represented as the average of three replicate trials. The statistical analysis is shown in Fig. 1.

  • b Determined by luciferase assay.

  • c Determined by fluorescence assay.

  • d ND, not determined.