Table 5.

Early mutations in serial passage experiments

DayPassage MIC (μg/ml)Mutation ina:
EF0631EF0716RpoNEF1753EF1797EF2470EF2698
Expt A
416N77_Q79delD30fs
532N77_Q79delwt/T99RbD30fs
13N77_Q79delW148_F150dupT99RD30fs
Expt B
416R218QI390fsI277F
532R218QI390fsI277F
14R218QI390fsV16insIS256I117SI277F
Expt C
48wt/R218Qbwt/I390fsb
516R218QI390fs
15R218QW148_F150delI390fsG130_F154delW82X
  • a Amino acid changes are shown.

  • b A mixture of wild-type (wt) and mutant alleles were detected.