Category | Parameter (units) | Model-fitted result | Bootstrap result^{c} | |||||
---|---|---|---|---|---|---|---|---|

No. of subjects | Estimate | % SE | % IIV | Median | 10th percentile | 90th percentile | ||

CMS | V1 (liters) | 105 | 11.5 | 32 | 102 | 93.9 | 113 | |

V2 (liters) | 105 | 18.7 | 9.0 | 79 | 99.4 | 85.6 | 124 | |

CLD1 (liters/h) | 105 | 7.98 | 12 | 84 | 97.0 | 77.8 | 117 | |

Random effects | CLR_{SLOPE} (liters/h/CrCL) | 89 | 0.0613 | 8.8 | 70 | 99.5 | 88.1 | 113 |

CLNR_{CMS} (liters/h) | 105 | 1.90 | 5.6 | 36 | 101 | 93.6 | 111 | |

Colistin | V3/fm (liters) | 105 | 45.1 | 6.1 | 48 | 102 | 90.1 | 116 |

CLT_{C}/fm (liters/h) | 105 | 2.72 | 23 | 100 | 92.0 | 110 | ||

Fixed effects | CLRC_{SL_POP}/fm (liters/h/CrCL) | 89 | 0.0147 | 28 | 102 | 68.0 | 142 | |

CLNR_{C}/fm (liters/h) | 105 | 2.19 | 5.8 | 99.1 | 92.7 | 107 | ||

V1_{POP} (liters/60 kg) | 105 | 11.9 | 5.1 | 103 | 94.1 | 113 | ||

Renal replacement^{b} | CLHD_{CMS} (liters/h) | 16 | 5.69 | 44 | 96 | |||

CLHD_{C} (liters/h) | 16 | 3.40 | 3.1 | 15 | ||||

CLRRT_{CMS} (liters/h) | 4 | 3.85 | 12 | 24 | ||||

CLRRT_{C} (liters/h) | 4 | 2.06 | 18 | 37 | ||||

Error variance | SD_{SLOPE_CMS} | 105 | 0.183 | 4.8 | 98.3 | 87.4 | 111 | |

SD_{SLOPE_C} | 105 | 0.099 | 4.1 | 99.0 | 85.8 | 114 | ||

SD_{INTERCEPT} | 105 | Fixed at LOQ | Fixed at LOQ | Fixed at LOQ |

↵a Estimates refer to the geometric mean of the estimates in the population. This may refer to the entire 105 subjects, 89 subjects not on any renal replacement, 16 subjects on some form of renal replacement, or 4 subjects on CRRT and is specified by the “No. of subjects” column. % SE refers to the standard error or the precision of the estimates, while % IIV refers to the interindividual variability in the population. LOQ refers to the limit of quantification.

↵b For the two RRT groups, the geometric mean, % SE, and % IIV are based on summary statistics of the

*post hoc*estimates in the indicated population.↵c Bootstrap results are expressed as a % of the model-fitted estimates.