Table 4.

Pharmacodynamic activity predicted by applying AUC0-24 valuesa for each of 105 critically ill patients together with PD parameters from 3 isolates of A. baumannii and 3 isolates of P. aeruginosa in murine thigh and lung infection modelsb

Study (reference)StrainMIC (mg/liter)% of cases corresponding to predicted magnitude of effectc
< stasisStasis to 1 log kill1 log kill to 2 log kill>2 log kill
P. aeruginosa murine thigh infection (12)190560.513.322.941.022.9
PAO1178.117.11.92.9
ATCC 27853195.21.90.02.9
P. aeruginosa murine lung infection (12)190560.51.017.153.328.6
PAO1136.252.48.62.9
ATCC 27853124.862.99.52.9
A. baumannii murine thigh infection (13)248-01-C.248112.468.616.22.9
N-16870.2130.57.611.422.958.1
ATCC 1960610.021.975.22.9
A. baumannii murine lung infection (13)248-01-C.248118.162.916.22.9
N-16870.2130.51.080.019.00.0
ATCC 1960610.017.180.02.9
  • a AUC0-24 values are from algorithm-predicted maintenance doses targeting a colistin Css,avg of 2.5 mg/liter.

  • b Unpublished PD parameter estimates referenced to the total plasma colistin concentration from references 12 and 13.

  • c Percentage of cases (105 patients) corresponding to various predicted effects relative to the respective baseline inocula.