Table 2.

Antibiofilm activity against MRSA-295

Treatment groupaMIC (μg/ml)bConcn (μg/ml)cLog10 no. of CFU/biofilm (mean ± SD)dLog reduction
InoculumNA8.24 ± 0.16
Control untreatedNA9.32 ± 0.07
DAP287.92 ± 0.160.32
165.38 ± 0.282.85
LZD2>648.51 ± 0.07−0.27
GEN247.97 ± 0.140.27
86.11 ± 0.212.13
SXT1>648.83 ± 0.01−0.59
VAN149.07 ± 0.09−0.82
86.02 ± 0.302.22
  • a Antibiotics currently on the market in our biofilm assay: daptomycin (DAP), linezolid (LZD), gentamicin (GEN), trimethoprim-sulfamethoxazole (SXT), and vancomycin (VAN).

  • b MIC was determined by broth microdilution.

  • c Biofilm assay. NA, not applicable.

  • d A minimum of two independent experiments were performed, with three wells per experiment. Data are reported as averages (n = 6 as a minimum) for these experiments.