Table 1.

MICs of MX-2401, vancomycin, and oxacillin against isolates of Gram-positive bacteria

OrganismDrug (no. of isolates tested)MIC (μg/ml)
Range50%90%
S. aureusaMX-2401 (15)0.25–40.52
Vancomycin (15)≤0.125–40.252
Oxacillin (10)≤0.125–>64>64>64
Coagulase-negativeMX-2401 (13)0.25–412
    staphylococcibVancomycin (13)≤0.125–422
Oxacillin (10)≤0.125–>643264
Enterococcus spp.cMX-2401 (18)0.25–424
Vancomycin (18)0.25–>64>64>64
Oxacillin (11)32–>64>64>64
Streptococcus spp.dMX-2401 (12)≤0.125–20.252
Vancomycin (12)≤0.125–20.251
Oxacillin (10)≤0.125–320.516
AnaerobeseMX-2401 (6)0.5–1NAfNA
Vancomycin (6)0.25–1NANA
Oxacillin (6)0.125–4NANA
  • a Includes methicillin-sensitive and -resistant, vancomycin-intermediate, tetracycline-resistant, and mupirocin-resistant S. aureus.

  • b Includes methicillin-sensitive and -resistant coagulase-negative staphylococci (including 11 strains of S. epidermidis).

  • c Includes vancomycin-sensitive and -resistant (VanA-, VanB-, and VanC-positive strains), linezolid-sensitive, -intermediate, and -resistant, quinupristin-dalfopristin-sensitive, -intermediate, and resistant, and tetracycline-resistant Enterococcus spp. (E. faecalis, E. faecium, and E. gallinarum).

  • d Includes penicillin-sensitive, -intermediate, and -resistant and erythromycin-sensitive and -resistant S. pneumoniae and azithromycin-resistant viridans group streptococci.

  • e Includes Peptostreptococcus magnus, Clostridium difficile, and erythromycin-resistant and -sensitive Propionibacterium acnes.

  • f NA, not available.